Anti-tumor effects of dual PI3K-HDAC inhibitor CUDC-907 on activation of ROS-IRE1α-JNK-mediated cytotoxic autophagy in esophageal cancer

BACKGROUND: PI3K-Akt pathway activation and the expression of histone deacetylases (HDACs) are highly increased in esophageal cancer, suggesting that inhibition of such targets may be a viable therapeutic strategy. Herein, we aimed to evaluate the anti-tumor effect of CUDC-907, a dual PI3K-HDAC inhi...

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Detalles Bibliográficos
Autores principales: Jian, Zheng, Han, Yichao, Zhang, Wentian, Li, Chengqiang, Guo, Wei, Feng, Xijia, Li, Bin, Li, Hecheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394063/
https://www.ncbi.nlm.nih.gov/pubmed/35989326
http://dx.doi.org/10.1186/s13578-022-00855-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394063/
https://www.ncbi.nlm.nih.gov/pubmed/35989326
http://dx.doi.org/10.1186/s13578-022-00855-x

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