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Anti-tumor effects of dual PI3K-HDAC inhibitor CUDC-907 on activation of ROS-IRE1α-JNK-mediated cytotoxic autophagy in esophageal cancer
BACKGROUND: PI3K-Akt pathway activation and the expression of histone deacetylases (HDACs) are highly increased in esophageal cancer, suggesting that inhibition of such targets may be a viable therapeutic strategy. Herein, we aimed to evaluate the anti-tumor effect of CUDC-907, a dual PI3K-HDAC inhi...
Autores principales: | Jian, Zheng, Han, Yichao, Zhang, Wentian, Li, Chengqiang, Guo, Wei, Feng, Xijia, Li, Bin, Li, Hecheng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394063/ https://www.ncbi.nlm.nih.gov/pubmed/35989326 http://dx.doi.org/10.1186/s13578-022-00855-x |
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