Single-cell analysis reveals clonally expanded tumor-associated CD57(+) CD8 T cells are enriched in the periphery of patients with metastatic urothelial cancer responding to PD-L1 blockade

BACKGROUND: A growing body of evidence suggests that T-cell responses against neoantigens are critical regulators of response to immune checkpoint blockade. We previously showed that circulating neoantigen-specific CD8 T cells in patients with lung cancer responding to anti-Programmed death-ligand 1...

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Detalles Bibliográficos
Autores principales: Fehlings, Michael, Kim, Leesun, Guan, Xiangnan, Yuen, Kobe, Tafazzol, Alireza, Sanjabi, Shomyseh, Zill, Oliver A, Rishipathak, Deepali, Wallace, Andrew, Nardin, Alessandra, Ma, Siming, Milojkovic, Ana, Newell, Evan W, Mariathasan, Sanjeev, Yadav, Mahesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Immunotherapy Biomarkers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394212/
https://www.ncbi.nlm.nih.gov/pubmed/35981786
http://dx.doi.org/10.1136/jitc-2022-004759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394212/
https://www.ncbi.nlm.nih.gov/pubmed/35981786
http://dx.doi.org/10.1136/jitc-2022-004759

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