Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 – a promising target for cancer immunotherapy

BACKGROUND: An important mechanism, by which cancer cells achieve immune escape, is the release of extracellular adenosine into their microenvironment. Adenosine activates adenosine A(2A) and A(2B) receptors on immune cells constituting one of the strongest immunosuppressive mediators. In addition,...

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Detalles Bibliográficos
Autores principales: Schäkel, Laura, Mirza, Salahuddin, Winzer, Riekje, Lopez, Vittoria, Idris, Riham, Al-Hroub, Haneen, Pelletier, Julie, Sévigny, Jean, Tolosa, Eva, Müller, Christa E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394215/
https://www.ncbi.nlm.nih.gov/pubmed/35981785
http://dx.doi.org/10.1136/jitc-2022-004660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394215/
https://www.ncbi.nlm.nih.gov/pubmed/35981785
http://dx.doi.org/10.1136/jitc-2022-004660

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