Discovery of Novel Dual Adenosine A(2A) and A(1) Receptor Antagonists with 1H-Pyrazolo[3,4-d]pyrimidin-6-amine Core Scaffold as Anti-Parkinson’s Disease Agents

New compounds with 1H-pyrazolo [3,4-d]pyrimidin-6-amine core scaffolds were synthesized and characterized in vitro to determine their affinity for human A(2A) and A(1) receptors. Among the tested compounds, a few compounds displayed nanomolar binding affinities for both receptors. One particular com...

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Detalles Bibliográficos
Autores principales: Jung, Juyoung, Lee, Yoonsuk, Moon, An-Na, Ann, Jihyae, Jeong, Jin Ju, Do, Nayeon, Lee, Jeewoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394284/
https://www.ncbi.nlm.nih.gov/pubmed/35893746
http://dx.doi.org/10.3390/ph15080922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394284/
https://www.ncbi.nlm.nih.gov/pubmed/35893746
http://dx.doi.org/10.3390/ph15080922

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