Discovery of Putative Dual Inhibitor of Tubulin and EGFR by Phenotypic Approach on LASSBio-1586 Homologs

Combretastatin A-4 (CA-4, 1) is an antimicrotubule agent used as a prototype for the design of several synthetic analogues with anti-tubulin activity, such as LASSBio-1586 (2). A series of branched and unbranched homologs of the lead-compound 2, and vinyl, ethinyl and benzyl analogues, were designed...

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Detalles Bibliográficos
Autores principales: Barbosa, Gisele, Gelves, Luis Gabriel Valdivieso, Costa, Caroline Marques Xavier, Franco, Lucas Silva, de Lima, João Alberto Lins, Aparecida-Silva, Cristiane, Teixeira, John Douglas, Mermelstein, Claudia dos Santos, Barreiro, Eliezer J., Lima, Lidia Moreira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394307/
https://www.ncbi.nlm.nih.gov/pubmed/35893736
http://dx.doi.org/10.3390/ph15080913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394307/
https://www.ncbi.nlm.nih.gov/pubmed/35893736
http://dx.doi.org/10.3390/ph15080913

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