TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing

TRIM7 catalyzes the ubiquitination of multiple substrates with unrelated biological functions. This cross-reactivity is at odds with the specificity usually displayed by enzymes, including ubiquitin ligases. Here we show that TRIM7′s extreme substrate promiscuity is due to a highly unusual binding m...

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Detalles Bibliográficos
Autores principales: Luptak, Jakub, Mallery, Donna L., Jahun, Aminu S., Albecka, Anna, Clift, Dean, Ather, Osaid, Slodkowicz, Greg, Goodfellow, Ian, James, Leo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394474/
https://www.ncbi.nlm.nih.gov/pubmed/35893676
http://dx.doi.org/10.3390/v14081610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394474/
https://www.ncbi.nlm.nih.gov/pubmed/35893676
http://dx.doi.org/10.3390/v14081610

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