TK216 targets microtubules in Ewing sarcoma cells

Ewing sarcoma (EWS) is a pediatric malignancy driven by the EWSR1-FLI1 fusion protein formed by the chromosomal translocation t(11; 22). The small molecule TK216 was developed as a first-in-class direct EWSR1-FLI1 inhibitor and is in phase II clinical trials in combination with vincristine for patie...

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Detalles Bibliográficos
Autores principales: Povedano, Juan Manuel, Li, Vicky, Lake, Katherine E., Bai, Xin, Rallabandi, Rameshu, Kim, Jiwoong, Xie, Yang, De Brabander, Jef K., McFadden, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394687/
https://www.ncbi.nlm.nih.gov/pubmed/35803262
http://dx.doi.org/10.1016/j.chembiol.2022.06.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394687/
https://www.ncbi.nlm.nih.gov/pubmed/35803262
http://dx.doi.org/10.1016/j.chembiol.2022.06.002

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