Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells

There is a growing appreciation that a tight relationship exists between cholesterol homeostasis and immunity in leukocytes; however, this relationship has not been deeply explored in the vascular endothelium. Endothelial cells (ECs) rapidly respond to extrinsic signals, such as tissue damage or mic...

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Detalles Bibliográficos
Autores principales: Fowler, Joseph Wayne M, Zhang, Rong, Tao, Bo, Boutagy, Nabil E, Sessa, William C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395194/
https://www.ncbi.nlm.nih.gov/pubmed/35959888
http://dx.doi.org/10.7554/eLife.79529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395194/
https://www.ncbi.nlm.nih.gov/pubmed/35959888
http://dx.doi.org/10.7554/eLife.79529

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