CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage

Clustered regularly interspaced short palindromic repeats (CRISPR)–Cas12a is widely used for genome editing and diagnostics, so it is important to understand how RNA-guided DNA recognition activates the cleavage of the target strand (TS) following non-target-strand (NTS) cleavage. Here we used singl...

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Detalles Bibliográficos
Autores principales: Naqvi, Mohsin M., Lee, Laura, Montaguth, Oscar E. Torres, Diffin, Fiona M., Szczelkun, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395263/
https://www.ncbi.nlm.nih.gov/pubmed/35836018
http://dx.doi.org/10.1038/s41589-022-01082-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395263/
https://www.ncbi.nlm.nih.gov/pubmed/35836018
http://dx.doi.org/10.1038/s41589-022-01082-8

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