A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity

Hepatic cell lines serve as economical and reproducible alternatives for primary human hepatocytes. However, the utility of hepatic cell lines to examine bile acid homeostasis and cholestatic toxicity is limited due to abnormal expression and function of bile acid-metabolizing enzymes, transporters,...

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Detalles Bibliográficos
Autores principales: Saran, Chitra, Fu, Dong, Ho, Henry, Klein, Abigail, Fallon, John K., Honkakoski, Paavo, Brouwer, Kim L. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395349/
https://www.ncbi.nlm.nih.gov/pubmed/35995956
http://dx.doi.org/10.1038/s41598-022-18174-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395349/
https://www.ncbi.nlm.nih.gov/pubmed/35995956
http://dx.doi.org/10.1038/s41598-022-18174-z

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