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Glomerular deposition of galactose-deficient IgA1-containing immune complexes via glomerular endothelial cell injuries

BACKGROUND: Galactose-deficient immunoglobulin A1 (Gd-IgA1) plays a crucial role in the development of IgA nephropathy (IgAN). However, the pathological role of Gd-IgA1-containing immune complexes (ICs) and the mechanism of deposition in the mesangial region remain unclear. METHODS: To examine the d...

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Detalles Bibliográficos
Autores principales: Makita, Yuko, Suzuki, Hitoshi, Nakano, Daisuke, Yanagawa, Hiroyuki, Kano, Toshiki, Novak, Jan, Nishiyama, Akira, Suzuki, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395370/
https://www.ncbi.nlm.nih.gov/pubmed/35746884
http://dx.doi.org/10.1093/ndt/gfac204