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Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology

Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are closely related progressive disorders with no available disease-modifying therapy, neuropathologically characterized by intraneuronal aggregates of misfolded α-synuclein. To explore the role of DNA methylation changes in PD and DLB pat...

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Detalles Bibliográficos
Autores principales: Pihlstrøm, Lasse, Shireby, Gemma, Geut, Hanneke, Henriksen, Sandra Pilar, Rozemuller, Annemieke J. M., Tunold, Jon-Anders, Hannon, Eilis, Francis, Paul, Thomas, Alan J., Love, Seth, Mill, Jonathan, van de Berg, Wilma D. J., Toft, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395387/
https://www.ncbi.nlm.nih.gov/pubmed/35995800
http://dx.doi.org/10.1038/s41467-022-32619-z