3D cell cultures, as a surrogate for animal models, enhance the diagnostic value of preclinical in vitro investigations by adding information on the tumour microenvironment: a comparative study of new dual-mode HDAC inhibitors

Anchorage-independent 3D-cultures of multicellular tumour spheroids (MCTS) and in vitro microtumours of cancer cells can provide upfront information on the effects of anticancer drug candidates, tantamount to that obtained from animal xenograft studies. Unlike 2D cancer cell cultures, 3D-models take...

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Detalles Bibliográficos
Autores principales: Bär, Sofia I., Biersack, Bernhard, Schobert, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395463/
https://www.ncbi.nlm.nih.gov/pubmed/35796910
http://dx.doi.org/10.1007/s10637-022-01280-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395463/
https://www.ncbi.nlm.nih.gov/pubmed/35796910
http://dx.doi.org/10.1007/s10637-022-01280-0

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