Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model

Novel approaches for malaria prophylaxis remain important. Synthetic DNA-encoded monoclonal antibodies (DMAbs) are a promising approach to generate rapid, direct in vivo host-generated mAbs with potential benefits in production simplicity and distribution coupled with genetic engineering. Here, we e...

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Detalles Bibliográficos
Autores principales: Tursi, Nicholas J., Reeder, Sophia M., Flores-Garcia, Yevel, Bah, Mamadou A., Mathis-Torres, Shamika, Salgado-Jimenez, Berenice, Esquivel, Rianne, Xu, Ziyang, Chu, Jacqueline D., Humeau, Laurent, Patel, Ami, Zavala, Fidel, Weiner, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395511/
https://www.ncbi.nlm.nih.gov/pubmed/35995959
http://dx.doi.org/10.1038/s41598-022-18375-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395511/
https://www.ncbi.nlm.nih.gov/pubmed/35995959
http://dx.doi.org/10.1038/s41598-022-18375-6

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