Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models

Considerable evidence supports the release of pathogenic aggregates of the neuronal protein α-Synuclein (αSyn) into the extracellular space. While this release is proposed to instigate the neuron-to-neuron transmission and spread of αSyn pathology in synucleinopathies including Parkinson’s disease,...

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Detalles Bibliográficos
Autores principales: Xie, Ying Xue, Naseri, Nima N., Fels, Jasmine, Kharel, Parinati, Na, Yoonmi, Lane, Diane, Burré, Jacqueline, Sharma, Manu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395532/
https://www.ncbi.nlm.nih.gov/pubmed/35995799
http://dx.doi.org/10.1038/s41467-022-32625-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395532/
https://www.ncbi.nlm.nih.gov/pubmed/35995799
http://dx.doi.org/10.1038/s41467-022-32625-1

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