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PLXND1-mediated calcium dyshomeostasis impairs endocardial endothelial autophagy in atrial fibrillation
Left atrial appendage (LAA) thrombus detachment resulting in intracranial embolism is a major complication of atrial fibrillation (AF). Endocardial endothelial cell (EEC) injury leads to thrombosis, whereas autophagy protects against EEC dysfunction. However, the role and underlying mechanisms of au...
Autores principales: | Sun, Mengjia, Chen, Zhen, Song, Yuanbin, Zhang, Bo, Yang, Jie, Tan, Hu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395636/ https://www.ncbi.nlm.nih.gov/pubmed/36017337 http://dx.doi.org/10.3389/fphys.2022.960480 |
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