The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1)

La-related protein 1 (LARP1) has been identified as a key translational inhibitor of terminal oligopyrimidine (TOP) mRNAs downstream of the nutrient sensing protein kinase complex, mTORC1. LARP1 exerts this inhibitory effect on TOP mRNA translation by binding to the mRNA cap and the adjacent 5′TOP m...

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Detalles Bibliográficos
Autores principales: Farooq, Zeenat, Kusuma, Fedho, Burke, Phillip, Dufour, Catherine R., Lee, Duckgue, Tabatabaei, Negar, Toboz, Phoenix, Radovani, Ernest, Greenblatt, Jack F., Rehman, Jalees, Class, Jacob, Khoutorsky, Arkady, Fonseca, Bruno D., Richner, Justin M., Mercier, Eloi, Bourque, Guillaume, Giguère, Vincent, Subramaniam, Arvind R., Han, Jaeseok, Tahmasebi, Soroush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396407/
https://www.ncbi.nlm.nih.gov/pubmed/35863436
http://dx.doi.org/10.1016/j.jbc.2022.102277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396407/
https://www.ncbi.nlm.nih.gov/pubmed/35863436
http://dx.doi.org/10.1016/j.jbc.2022.102277

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