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A flux-based machine learning model to simulate the impact of pathogen metabolic heterogeneity on drug interactions
Drug combinations are a promising strategy to counter antibiotic resistance. However, current experimental and computational approaches do not account for the entire complexity involved in combination therapy design, such as the effect of pathogen metabolic heterogeneity, changes in the growth envir...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396445/ https://www.ncbi.nlm.nih.gov/pubmed/36016709 http://dx.doi.org/10.1093/pnasnexus/pgac132 |