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A flux-based machine learning model to simulate the impact of pathogen metabolic heterogeneity on drug interactions

Drug combinations are a promising strategy to counter antibiotic resistance. However, current experimental and computational approaches do not account for the entire complexity involved in combination therapy design, such as the effect of pathogen metabolic heterogeneity, changes in the growth envir...

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Detalles Bibliográficos
Autores principales: Chung, Carolina H, Chandrasekaran, Sriram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396445/
https://www.ncbi.nlm.nih.gov/pubmed/36016709
http://dx.doi.org/10.1093/pnasnexus/pgac132

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