Probing the Role of Murine Neuroglobin CDloop–D-Helix Unit in CO Ligand Binding and Structural Dynamics

[Image: see text] We produced a neuroglobin variant, namely, Ngb CDless, with the excised CDloop- and D-helix, directly joining the C- and E-helices. The CDless variant retained bis-His hexacoordination, and we investigated the role of the CDloop–D-helix unit in controlling the CO binding and struct...

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Detalles Bibliográficos
Autores principales: Exertier, Cécile, Sebastiani, Federico, Freda, Ida, Gugole, Elena, Cerutti, Gabriele, Parisi, Giacomo, Montemiglio, Linda Celeste, Becucci, Maurizio, Viappiani, Cristiano, Bruno, Stefano, Savino, Carmelinda, Zamparelli, Carlotta, Anselmi, Massimiliano, Abbruzzetti, Stefania, Smulevich, Giulietta, Vallone, Beatrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396615/
https://www.ncbi.nlm.nih.gov/pubmed/35797699
http://dx.doi.org/10.1021/acschembio.2c00172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396615/
https://www.ncbi.nlm.nih.gov/pubmed/35797699
http://dx.doi.org/10.1021/acschembio.2c00172

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