Biosynthesis of Largimycins in Streptomyces argillaceus Involves Transient β-Alkylation and Cryptic Halogenation Steps Unprecedented in the Leinamycin Family

[Image: see text] Largimycins A1 and A2 are key members of a recently identified family of hybrid nonribosomal peptide polyketides belonging to the scarcely represented group of antitumor leinamycins. They are encoded by the gene cluster lrg of Streptomyces argillaceus. This cluster contains a halog...

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Detalles Bibliográficos
Autores principales: Becerril, Adriana, Pérez-Victoria, Ignacio, Martín, Jesús M., Reyes, Fernando, Salas, Jose A., Méndez, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396626/
https://www.ncbi.nlm.nih.gov/pubmed/35830174
http://dx.doi.org/10.1021/acschembio.2c00416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396626/
https://www.ncbi.nlm.nih.gov/pubmed/35830174
http://dx.doi.org/10.1021/acschembio.2c00416

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