Design, synthesis, and biological screening of a series of 4′-fluoro-benzotriazole-acrylonitrile derivatives as microtubule-destabilising agents (MDAs)

Introduction: Colchicine-binding site inhibitors are some of the most interesting ligands belonging to the wider family of microtubule-destabilising agents. Results: A novel series of 4′-fluoro-substituted ligands (5–13) was synthesised. The antiproliferative activity assays resulted in nM values fo...

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Detalles Bibliográficos
Autores principales: Riu, Federico, Ibba, Roberta, Zoroddu, Stefano, Sestito, Simona, Lai, Michele, Piras, Sandra, Sanna, Luca, Bordoni, Valentina, Bagella, Luigi, Carta, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397482/
https://www.ncbi.nlm.nih.gov/pubmed/35979600
http://dx.doi.org/10.1080/14756366.2022.2111680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397482/
https://www.ncbi.nlm.nih.gov/pubmed/35979600
http://dx.doi.org/10.1080/14756366.2022.2111680

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