Subclone Eradication Analysis Identifies Targets for Enhanced Cancer Therapy and Reveals L1 Retrotransposition as a Dynamic Source of Cancer Heterogeneity

Treatment-eradicated cancer subclones have been reported in leukemia and have recently been detected in solid tumors. Here we introduce Differential Subclone Eradication and Resistance (DSER) analysis, a method developed to identify molecular targets for improved therapy by direct comparison of geno...

Descripción completa

Detalles Bibliográficos
Autores principales: Ketola, Kirsi, Kaljunen, Heidi, Taavitsainen, Sinja, Kaarijärvi, Roosa, Järvelä, Emmi, Rodríguez-Martín, Bernardo, Haase, Kerstin, Woodcock, Dan J., Tubio, Jose, Wedge, David C., Nykter, Matti, Bova, G. Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Priority Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397610/
https://www.ncbi.nlm.nih.gov/pubmed/34348967
http://dx.doi.org/10.1158/0008-5472.CAN-21-0371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397610/
https://www.ncbi.nlm.nih.gov/pubmed/34348967
http://dx.doi.org/10.1158/0008-5472.CAN-21-0371

Ejemplares similares