Changes in physicochemical and anticancer properties modulated by chemically modified sugar moieties within sequence-related G-quadruplex structures

We systematically investigated the influence of locked nucleic acid (LNA), unlock nucleic acid (UNA), and 2’-O-methyl-RNA (2’-O-Me-RNA) residues on the thermal stability, structure folding topology, biological activity and enzymatic resistance of three sequence-related DNA G-quadruplexes. In order t...

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Detalles Bibliográficos
Autores principales: Roxo, Carolina, Pasternak, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397905/
https://www.ncbi.nlm.nih.gov/pubmed/35998148
http://dx.doi.org/10.1371/journal.pone.0273528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397905/
https://www.ncbi.nlm.nih.gov/pubmed/35998148
http://dx.doi.org/10.1371/journal.pone.0273528

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