2-deoxyglucose transiently inhibits yeast AMPK signaling and triggers glucose transporter endocytosis, potentiating the drug toxicity

2-deoxyglucose is a glucose analog that impacts many aspects of cellular physiology. After its uptake and its phosphorylation into 2-deoxyglucose-6-phosphate (2DG6P), it interferes with several metabolic pathways including glycolysis and protein N-glycosylation. Despite this systemic effect, resista...

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Detalles Bibliográficos
Autores principales: Laussel, Clotilde, Albanèse, Véronique, García-Rodríguez, Francisco Javier, Ballin, Alberto, Defenouillère, Quentin, Léon, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398028/
https://www.ncbi.nlm.nih.gov/pubmed/35951639
http://dx.doi.org/10.1371/journal.pgen.1010169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398028/
https://www.ncbi.nlm.nih.gov/pubmed/35951639
http://dx.doi.org/10.1371/journal.pgen.1010169

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