Comparative Analysis of Total Alpha-Synuclein (αSYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified αSYN Proteoforms

BACKGROUND: The development of therapeutics for Parkinson’s disease (PD) requires the establishment of biomarker assays to enable stratifying patients, monitoring disease progression, and assessing target engagement. Attempts to develop diagnostic assays based on detecting levels of the α-synuclein...

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Detalles Bibliográficos
Autores principales: Petricca, Lara, Chiki, Nour, Hanna-El-Daher, Layane, Aeschbach, Lorène, Burai, Ritwik, Stoops, Erik, Fares, Mohamed-Bilal, Lashuel, Hilal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398082/
https://www.ncbi.nlm.nih.gov/pubmed/35527570
http://dx.doi.org/10.3233/JPD-223285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398082/
https://www.ncbi.nlm.nih.gov/pubmed/35527570
http://dx.doi.org/10.3233/JPD-223285

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