Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects

DNA methyltransferase inhibitors have improved the prognosis of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). However, because these agents are easily degraded by cytidine deaminase (CDA), they must be administered intravenously or subcutaneously. Recently, two orally bioavailable...

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Detalles Bibliográficos
Autores principales: Ureshino, Hiroshi, Kurahashi, Yuki, Watanabe, Tatsuro, Yamashita, Satoshi, Kamachi, Kazuharu, Yamamoto, Yuta, Fukuda-Kurahashi, Yuki, Yoshida-Sakai, Nao, Hattori, Naoko, Hayashi, Yoshihiro, Kawaguchi, Atsushi, Tohyama, Kaoru, Okada, Seiji, Harada, Hironori, Ushijima, Toshikazu, Kimura, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398096/
https://www.ncbi.nlm.nih.gov/pubmed/34045225
http://dx.doi.org/10.1158/1535-7163.MCT-20-1125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398096/
https://www.ncbi.nlm.nih.gov/pubmed/34045225
http://dx.doi.org/10.1158/1535-7163.MCT-20-1125

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