NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis

Patients with hepatocellular carcinoma (HCC) suffer from few treatment options and poor survival rates. Here we report that endonuclease VIII-like protein 3 (NEIL3) is overexpressed in HCC and correlates with poor survival. All six HCC cell lines investigated were dependent on NEIL3 catalytic activi...

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Detalles Bibliográficos
Autores principales: Zhao, Zhenjun, Gad, Helge, Benitez-Buelga, Carlos, Sanjiv, Kumar, Xiangwei, Hua, Kang, He, Feng, Mingxuan, Zhao, Zhicong, Berglund, Ulrika Warpman, Xia, Qiang, Helleday, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Molecular Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398161/
https://www.ncbi.nlm.nih.gov/pubmed/34045188
http://dx.doi.org/10.1158/0008-5472.CAN-20-1028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398161/
https://www.ncbi.nlm.nih.gov/pubmed/34045188
http://dx.doi.org/10.1158/0008-5472.CAN-20-1028

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