M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (β5i) Delivering Efficacy in Multiple Myeloma Models

Large multifunctional peptidase 7 (LMP7/β5i/PSMB8) is a proteolytic subunit of the immunoproteasome, which is predominantly expressed in normal and malignant hematolymphoid cells, including multiple myeloma, and contributes to the degradation of ubiquitinated proteins. Described herein for the first...

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Detalles Bibliográficos
Autores principales: Sanderson, Michael P., Friese-Hamim, Manja, Walter-Bausch, Gina, Busch, Michael, Gaus, Stefanie, Musil, Djordje, Rohdich, Felix, Zanelli, Ugo, Downey-Kopyscinski, Sondra L., Mitsiades, Constantine S., Schadt, Oliver, Klein, Markus, Esdar, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398180/
https://www.ncbi.nlm.nih.gov/pubmed/34045234
http://dx.doi.org/10.1158/1535-7163.MCT-21-0005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398180/
https://www.ncbi.nlm.nih.gov/pubmed/34045234
http://dx.doi.org/10.1158/1535-7163.MCT-21-0005

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