Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition

Protein phosphatase 2A (PP2A) holoenzymes target broad substrates by recognizing short motifs via regulatory subunits. PP2A methylesterase 1 (PME-1) is a cancer-promoting enzyme and undergoes methylesterase activation upon binding to the PP2A core enzyme. Here, we showed that PME-1 readily demethyla...

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Detalles Bibliográficos
Autores principales: Li, Yitong, Balakrishnan, Vijaya Kumar, Rowse, Michael, Wu, Cheng-Guo, Bravos, Anastasia Phoebe, Yadav, Vikash K, Ivarsson, Ylva, Strack, Stefan, Novikova, Irina V, Xing, Yongna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398451/
https://www.ncbi.nlm.nih.gov/pubmed/35924897
http://dx.doi.org/10.7554/eLife.79736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398451/
https://www.ncbi.nlm.nih.gov/pubmed/35924897
http://dx.doi.org/10.7554/eLife.79736

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