Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus

Interactions between a T cell receptor (TCR) and a peptide-major histocompatibility complex (pMHC) ligand are typically mediated by noncovalent bonds. By studying T cells expressing natural or engineered TCRs, here we describe covalent TCR-pMHC interactions that involve a cysteine-cysteine disulfide...

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Detalles Bibliográficos
Autores principales: Szeto, Christopher, Zareie, Pirooz, Wirasinha, Rushika C., Zhang, Justin B., Nguyen, Andrea T., Riboldi-Tunnicliffe, Alan, La Gruta, Nicole L., Gras, Stephanie, Daley, Stephen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399087/
https://www.ncbi.nlm.nih.gov/pubmed/35999236
http://dx.doi.org/10.1038/s41467-022-32692-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399087/
https://www.ncbi.nlm.nih.gov/pubmed/35999236
http://dx.doi.org/10.1038/s41467-022-32692-4

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