Cargando…

Loureirin B downregulates osteoclast differentiation of bone marrow macrophages by targeting the MAPK signaling pathway

Excessive absorption of osteoclasts will break the balance between osteoclasts and osteoblasts, leading to bone loss, decreased bone density, and increased bone fragility. We have shown that Loureirin B (LrB) can inhibit osteoclasts. In this study, we demonstrated the targeting-inhibitory mechanism...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jiahao, Mo, Liang, Huang, Haoran, Xu, Jiake, Fan, Yinuo, Li, Weifeng, Wang, Haibin, Zhou, Chi, Fang, Hanjun, He, Wei, Chen, Zhenqiu, Liu, Yuhao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399088/ https://www.ncbi.nlm.nih.gov/pubmed/35999378 http://dx.doi.org/10.1038/s41598-022-18287-5

Ejemplares similares

Loureirin B suppresses RANKL-induced osteoclastogenesis and ovariectomized osteoporosis via attenuating NFATc1 and ROS activities
por: Liu, Yuhao, et al.
Publicado: (2019)

Dragon blood resin ameliorates steroid-induced osteonecrosis of femoral head through osteoclastic pathways
por: Liu, Yuhao, et al.
Publicado: (2023)

Clinical Outcome of Surgical Hip Dislocation Combined with Impacting Bone Grafts and Implanting Iliac Bone Flaps in the Treatment of Osteonecrosis of the Femoral Head: A Mid‐term Retrospective Study
por: Zhou, Chi, et al.
Publicado: (2022)

Evaluation of the predictive values of collapse and necrotic lesion boundary for osteonecrosis of the femoral head prognosis
por: Fan, Yinuo, et al.
Publicado: (2023)

Dehydromiltirone inhibits osteoclast differentiation in RAW264.7 and bone marrow macrophages by modulating MAPK and NF-κB activity
por: Deng, Wei, et al.
Publicado: (2022)

The immunosuppressive effects and mechanisms of loureirin B on collagen-induced arthritis in rats
por: Zou, Yan, et al.
Publicado: (2023)

Sclerostin expression in trabecular bone is downregulated by osteoclasts
por: Koide, Masanori, et al.
Publicado: (2020)

Effect of ProRoot MTA(®) and Biodentine(®) on osteoclastic differentiation and activity of mouse bone marrow macrophages
por: Kim, Miri, et al.
Publicado: (2019)

Osteoclast Differentiation is Downregulated by Select Polyphenolic Fractions from Dried Plum via Suppression of MAPKs and Nfatc1 in Mouse C57BL/6 Primary Bone Marrow Cells
por: Graef, Jennifer L, et al.
Publicado: (2017)

Theoretical and Experimental Investigation of the Antioxidation Mechanism of Loureirin C by Radical Scavenging for Treatment of Stroke
por: Liu, Ye-Shu, et al.
Publicado: (2023)

Ginsenoside Re Inhibits Osteoclast Differentiation in Mouse Bone Marrow-Derived Macrophages and Zebrafish Scale Model
por: Park, Chan-Mi, et al.
Publicado: (2016)

Thioacetamide promotes osteoclast transformation of bone marrow macrophages by influencing PI3K/AKT pathways
por: Jin, XiaoLi, et al.
Publicado: (2022)

Interleukin-17A facilitates osteoclast differentiation and bone resorption via activation of autophagy in mouse bone marrow macrophages
por: Song, Lu, et al.
Publicado: (2019)

Loureirin B activates GLP‐1R and promotes insulin secretion in Ins‐1 cells
por: Ding, Yanting, et al.
Publicado: (2020)

Loureirin A Exerts Antikeloid Activity by Antagonizing the TGF-β1/Smad Signalling Pathway
por: Ma, Hui, et al.
Publicado: (2022)

Simulated Microgravity Altered the Metabolism of Loureirin B and the Expression of Major Cytochrome P450 in Liver of Rats
por: Chen, Bo, et al.
Publicado: (2018)

The association the patient-reported outcomes after periacetabular osteotomy with radiographic features: a short-term retrospective study
por: Fan, Yinuo, et al.
Publicado: (2021)

Conditional Knockout of PKC-δ in Osteoclasts Favors Bone Mass Accrual in Males Due to Decreased Osteoclast Function
por: Li, Shangfu, et al.
Publicado: (2020)

Chronological differential effects of pro-inflammatory cytokines on RANKL-induced osteoclast differentiation of canine bone marrow-derived macrophages
por: WIJEKOON, Suranji, et al.
Publicado: (2017)

Neuropilin‐1‐Mediated SARS‐CoV‐2 Infection in Bone Marrow‐Derived Macrophages Inhibits Osteoclast Differentiation
por: Gao, Junjie, et al.
Publicado: (2022)

Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow
por: Mansour, Anna, et al.
Publicado: (2012)

Comparative Characterization of Osteoclasts Derived From Murine Bone Marrow Macrophages and RAW 264.7 Cells Using Quantitative Proteomics
por: Ng, Andrew YH, et al.
Publicado: (2018)

Three Scrophularia Species (Scrophularia buergeriana, S. koraiensis, and S. takesimensis) Inhibit RANKL-Induced Osteoclast Differentiation in Bone Marrow-Derived Macrophages
por: Nam, Hyeon-Hwa, et al.
Publicado: (2020)

Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells
por: Yokota, Hiroki, et al.
Publicado: (2013)

Bioactivity-Guided Fractionation of the Traditional Chinese Medicine Resina Draconis Reveals Loureirin B as a PAI-1 Inhibitor
por: Jiang, Yu, et al.
Publicado: (2017)

Melphalan modifies the bone microenvironment by enhancing osteoclast formation
por: Chai, Ryan C., et al.
Publicado: (2017)

Calmodulin interacts with Rab3D and modulates osteoclastic bone resorption
por: Zhu, Sipin, et al.
Publicado: (2016)

In vitro formation of osteoclasts from long-term cultures of bone marrow mononuclear phagocytes
Publicado: (1982)

Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone
por: Zhong, Leilei, et al.
Publicado: (2023)

Reduced osteoclast-derived apoptotic bodies in bone marrow characterizes the pathological progression of osteoporosis
por: Wu, Yutong, et al.
Publicado: (2023)

Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and K(V)1.3 Channels
por: Shi, Shujuan, et al.
Publicado: (2021)

Donepezil prevents RANK-induced bone loss via inhibition of osteoclast differentiation by downregulating acetylcholinesterase
por: Sato, Tsuyoshi, et al.
Publicado: (2015)

Surfactin inducing mitochondria-dependent ROS to activate MAPKs, NF-κB and inflammasomes in macrophages for adjuvant activity
por: Gan, Ping, et al.
Publicado: (2016)

Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts
por: Chen, Kai, et al.
Publicado: (2020)

Targeting Bone Marrow Niche Macrophages: The Novel Frontier in Bone Marrow Transplant
por: Vinchi, Francesca
Publicado: (2018)

Rhus javanica Gall Extract Inhibits the Differentiation of Bone Marrow-Derived Osteoclasts and Ovariectomy-Induced Bone Loss
por: Kim, Tae-Ho, et al.
Publicado: (2016)

Bone Marrow Derived Extracellular Vesicles Activate Osteoclast Differentiation in Traumatic Brain Injury Induced Bone Loss
por: Singleton, Quante, et al.
Publicado: (2019)

Loureirin B, an essential component of Sanguis Draxonis, inhibits Kv1.3 channel and suppresses cytokine release from Jurkat T cells
por: Yin, Shijin, et al.
Publicado: (2014)

Loureirin B Alleviates Myocardial Ischemia/Reperfusion Injury via Inhibiting PAI-1/TGF-β1/Smad Signaling Pathway
por: Kong, Fei, et al.
Publicado: (2022)

Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling
por: Zhou, Lin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_njou7r0lc660km1q5neakcgv8n