Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade

Radiation therapy (RT) activates an in situ vaccine effect when combined with immune checkpoint blockade (ICB), yet this effect may be limited because RT does not fully optimize tumor antigen presentation or fully overcome suppressive mechanisms in the tumor-immune microenvironment. To overcome this...

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Detalles Bibliográficos
Autores principales: Zhang, Ying, Sriramaneni, Raghava N., Clark, Paul A., Jagodinsky, Justin C., Ye, Mingzhou, Jin, Wonjong, Wang, Yuyuan, Bates, Amber, Kerr, Caroline P., Le, Trang, Allawi, Raad, Wang, Xiuxiu, Xie, Ruosen, Havighurst, Thomas C., Chakravarty, Ishan, Rakhmilevich, Alexander L., O’Leary, Kathleen A., Schuler, Linda A., Sondel, Paul M., Kim, Kyungmann, Gong, Shaoqin, Morris, Zachary S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399096/
https://www.ncbi.nlm.nih.gov/pubmed/35999216
http://dx.doi.org/10.1038/s41467-022-32645-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399096/
https://www.ncbi.nlm.nih.gov/pubmed/35999216
http://dx.doi.org/10.1038/s41467-022-32645-x

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