Cargando…
Estimating effects of parents’ cognitive and non-cognitive skills on offspring education using polygenic scores
Understanding how parents’ cognitive and non-cognitive skills influence offspring education is essential for educational, family and economic policy. We use genetics (GWAS-by-subtraction) to assess a latent, broad non-cognitive skills dimension. To index parental effects controlling for genetic tran...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399113/ https://www.ncbi.nlm.nih.gov/pubmed/35999215 http://dx.doi.org/10.1038/s41467-022-32003-x |
_version_ | 1784772451286122496 |
---|---|
author | Demange, Perline A. Hottenga, Jouke Jan Abdellaoui, Abdel Eilertsen, Espen Moen Malanchini, Margherita Domingue, Benjamin W. Armstrong-Carter, Emma de Zeeuw, Eveline L. Rimfeld, Kaili Boomsma, Dorret I. van Bergen, Elsje Breen, Gerome Nivard, Michel G. Cheesman, Rosa |
author_facet | Demange, Perline A. Hottenga, Jouke Jan Abdellaoui, Abdel Eilertsen, Espen Moen Malanchini, Margherita Domingue, Benjamin W. Armstrong-Carter, Emma de Zeeuw, Eveline L. Rimfeld, Kaili Boomsma, Dorret I. van Bergen, Elsje Breen, Gerome Nivard, Michel G. Cheesman, Rosa |
author_sort | Demange, Perline A. |
collection | PubMed |
description | Understanding how parents’ cognitive and non-cognitive skills influence offspring education is essential for educational, family and economic policy. We use genetics (GWAS-by-subtraction) to assess a latent, broad non-cognitive skills dimension. To index parental effects controlling for genetic transmission, we estimate indirect parental genetic effects of polygenic scores on childhood and adulthood educational outcomes, using siblings (N = 47,459), adoptees (N = 6407), and parent-offspring trios (N = 2534) in three UK and Dutch cohorts. We find that parental cognitive and non-cognitive skills affect offspring education through their environment: on average across cohorts and designs, indirect genetic effects explain 36–40% of population polygenic score associations. However, indirect genetic effects are lower for achievement in the Dutch cohort, and for the adoption design. We identify potential causes of higher sibling- and trio-based estimates: prenatal indirect genetic effects, population stratification, and assortative mating. Our phenotype-agnostic, genetically sensitive approach has established overall environmental effects of parents’ skills, facilitating future mechanistic work. |
format | Online Article Text |
id | pubmed-9399113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-93991132022-08-25 Estimating effects of parents’ cognitive and non-cognitive skills on offspring education using polygenic scores Demange, Perline A. Hottenga, Jouke Jan Abdellaoui, Abdel Eilertsen, Espen Moen Malanchini, Margherita Domingue, Benjamin W. Armstrong-Carter, Emma de Zeeuw, Eveline L. Rimfeld, Kaili Boomsma, Dorret I. van Bergen, Elsje Breen, Gerome Nivard, Michel G. Cheesman, Rosa Nat Commun Article Understanding how parents’ cognitive and non-cognitive skills influence offspring education is essential for educational, family and economic policy. We use genetics (GWAS-by-subtraction) to assess a latent, broad non-cognitive skills dimension. To index parental effects controlling for genetic transmission, we estimate indirect parental genetic effects of polygenic scores on childhood and adulthood educational outcomes, using siblings (N = 47,459), adoptees (N = 6407), and parent-offspring trios (N = 2534) in three UK and Dutch cohorts. We find that parental cognitive and non-cognitive skills affect offspring education through their environment: on average across cohorts and designs, indirect genetic effects explain 36–40% of population polygenic score associations. However, indirect genetic effects are lower for achievement in the Dutch cohort, and for the adoption design. We identify potential causes of higher sibling- and trio-based estimates: prenatal indirect genetic effects, population stratification, and assortative mating. Our phenotype-agnostic, genetically sensitive approach has established overall environmental effects of parents’ skills, facilitating future mechanistic work. Nature Publishing Group UK 2022-08-23 /pmc/articles/PMC9399113/ /pubmed/35999215 http://dx.doi.org/10.1038/s41467-022-32003-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Demange, Perline A. Hottenga, Jouke Jan Abdellaoui, Abdel Eilertsen, Espen Moen Malanchini, Margherita Domingue, Benjamin W. Armstrong-Carter, Emma de Zeeuw, Eveline L. Rimfeld, Kaili Boomsma, Dorret I. van Bergen, Elsje Breen, Gerome Nivard, Michel G. Cheesman, Rosa Estimating effects of parents’ cognitive and non-cognitive skills on offspring education using polygenic scores |
title | Estimating effects of parents’ cognitive and non-cognitive skills on offspring education using polygenic scores |
title_full | Estimating effects of parents’ cognitive and non-cognitive skills on offspring education using polygenic scores |
title_fullStr | Estimating effects of parents’ cognitive and non-cognitive skills on offspring education using polygenic scores |
title_full_unstemmed | Estimating effects of parents’ cognitive and non-cognitive skills on offspring education using polygenic scores |
title_short | Estimating effects of parents’ cognitive and non-cognitive skills on offspring education using polygenic scores |
title_sort | estimating effects of parents’ cognitive and non-cognitive skills on offspring education using polygenic scores |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399113/ https://www.ncbi.nlm.nih.gov/pubmed/35999215 http://dx.doi.org/10.1038/s41467-022-32003-x |
work_keys_str_mv | AT demangeperlinea estimatingeffectsofparentscognitiveandnoncognitiveskillsonoffspringeducationusingpolygenicscores AT hottengajoukejan estimatingeffectsofparentscognitiveandnoncognitiveskillsonoffspringeducationusingpolygenicscores AT abdellaouiabdel estimatingeffectsofparentscognitiveandnoncognitiveskillsonoffspringeducationusingpolygenicscores AT eilertsenespenmoen estimatingeffectsofparentscognitiveandnoncognitiveskillsonoffspringeducationusingpolygenicscores AT malanchinimargherita estimatingeffectsofparentscognitiveandnoncognitiveskillsonoffspringeducationusingpolygenicscores AT dominguebenjaminw estimatingeffectsofparentscognitiveandnoncognitiveskillsonoffspringeducationusingpolygenicscores AT armstrongcarteremma estimatingeffectsofparentscognitiveandnoncognitiveskillsonoffspringeducationusingpolygenicscores AT dezeeuwevelinel estimatingeffectsofparentscognitiveandnoncognitiveskillsonoffspringeducationusingpolygenicscores AT rimfeldkaili estimatingeffectsofparentscognitiveandnoncognitiveskillsonoffspringeducationusingpolygenicscores AT boomsmadorreti estimatingeffectsofparentscognitiveandnoncognitiveskillsonoffspringeducationusingpolygenicscores AT vanbergenelsje estimatingeffectsofparentscognitiveandnoncognitiveskillsonoffspringeducationusingpolygenicscores AT breengerome estimatingeffectsofparentscognitiveandnoncognitiveskillsonoffspringeducationusingpolygenicscores AT nivardmichelg estimatingeffectsofparentscognitiveandnoncognitiveskillsonoffspringeducationusingpolygenicscores AT cheesmanrosa estimatingeffectsofparentscognitiveandnoncognitiveskillsonoffspringeducationusingpolygenicscores |