Integrating cell morphology with gene expression and chemical structure to aid mitochondrial toxicity detection

Mitochondrial toxicity is an important safety endpoint in drug discovery. Models based solely on chemical structure for predicting mitochondrial toxicity are currently limited in accuracy and applicability domain to the chemical space of the training compounds. In this work, we aimed to utilize both...

Descripción completa

Detalles Bibliográficos
Autores principales: Seal, Srijit, Carreras-Puigvert, Jordi, Trapotsi, Maria-Anna, Yang, Hongbin, Spjuth, Ola, Bender, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399120/
https://www.ncbi.nlm.nih.gov/pubmed/35999457
http://dx.doi.org/10.1038/s42003-022-03763-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399120/
https://www.ncbi.nlm.nih.gov/pubmed/35999457
http://dx.doi.org/10.1038/s42003-022-03763-5

Ejemplares similares