Genome-wide mutational signatures in low-coverage whole genome sequencing of cell-free DNA

Mutational signatures accumulate in somatic cells as an admixture of endogenous and exogenous processes that occur during an individual’s lifetime. Since dividing cells release cell-free DNA (cfDNA) fragments into the circulation, we hypothesize that plasma cfDNA might reflect mutational signatures....

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Detalles Bibliográficos
Autores principales: Wan, Jonathan C. M., Stephens, Dennis, Luo, Lingqi, White, James R., Stewart, Caitlin M., Rousseau, Benoît, Tsui, Dana W. Y., Diaz, Luis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399180/
https://www.ncbi.nlm.nih.gov/pubmed/35999207
http://dx.doi.org/10.1038/s41467-022-32598-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399180/
https://www.ncbi.nlm.nih.gov/pubmed/35999207
http://dx.doi.org/10.1038/s41467-022-32598-1

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