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Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals
In mammals, the circadian clock consists of transcriptional and translational feedback loops through DNA cis-elements such as E-box and RRE. The E-box-mediated core feedback loop is interlocked with the RRE-mediated feedback loop, but biological significance of the RRE-mediated loop has been elusive...
Autores principales: | Abe, Yasuko O., Yoshitane, Hikari, Kim, Dae Wook, Kawakami, Satoshi, Koebis, Michinori, Nakao, Kazuki, Aiba, Atsu, Kim, Jae Kyoung, Fukada, Yoshitaka |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399252/ https://www.ncbi.nlm.nih.gov/pubmed/35999195 http://dx.doi.org/10.1038/s41467-022-32326-9 |
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