Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks

Elevated DNA replication stress causes instability of the DNA replication fork and increased DNA mutations, which underlies tumorigenesis. The DNA replication stress regulator silencing-defective 2 (SDE2) is known to bind to TIMELESS (TIM), a protein of the fork protection complex, and enhances its...

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Detalles Bibliográficos
Autores principales: Weinheimer, Alexandra S., Paung, YiTing, Rageul, Julie, Khan, Arafat, Lo, Natalie, Ho, Brian, Tong, Michael, Alphonse, Sébastien, Seeliger, Markus A., Kim, Hyungjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399289/
https://www.ncbi.nlm.nih.gov/pubmed/35850305
http://dx.doi.org/10.1016/j.jbc.2022.102268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399289/
https://www.ncbi.nlm.nih.gov/pubmed/35850305
http://dx.doi.org/10.1016/j.jbc.2022.102268

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