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Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division

Mixed lineage kinase 3 (MLK3) is a serine/threonine mitogen-activated protein kinase kinase kinase that promotes the activation of multiple mitogen-activated protein kinase pathways and is required for invasion and proliferation of ovarian cancer cells. Inhibition of MLK activity causes G2/M arrest...

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Detalles Bibliográficos
Autores principales: Cedeno-Rosario, Luis, Honda, David, Sunderland, Autumn M., Lewandowski, Mark D., Taylor, William R., Chadee, Deborah N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399292/
https://www.ncbi.nlm.nih.gov/pubmed/35843311
http://dx.doi.org/10.1016/j.jbc.2022.102263