CD8 T cell function and cross-reactivity explored by stepwise increased peptide-HLA versus TCR affinity

Recruitment and activation of CD8 T cells occur through specific triggering of T cell receptor (TCR) by peptide-bound human leucocyte antigen (HLA) ligands. Within the generated trimeric TCR-peptide:HLA complex, the molecular binding affinities between peptide and HLA, and between TCR and peptide:HL...

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Detalles Bibliográficos
Autores principales: Baumgaertner, Petra, Schmidt, Julien, Costa-Nunes, Carla-Marisa, Bordry, Natacha, Guillaume, Philippe, Luescher, Immanuel, Speiser, Daniel E., Rufer, Nathalie, Hebeisen, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399405/
https://www.ncbi.nlm.nih.gov/pubmed/36032094
http://dx.doi.org/10.3389/fimmu.2022.973986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399405/
https://www.ncbi.nlm.nih.gov/pubmed/36032094
http://dx.doi.org/10.3389/fimmu.2022.973986

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