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CD8 T cell function and cross-reactivity explored by stepwise increased peptide-HLA versus TCR affinity

Recruitment and activation of CD8 T cells occur through specific triggering of T cell receptor (TCR) by peptide-bound human leucocyte antigen (HLA) ligands. Within the generated trimeric TCR-peptide:HLA complex, the molecular binding affinities between peptide and HLA, and between TCR and peptide:HL...

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Detalles Bibliográficos
Autores principales:	Baumgaertner, Petra, Schmidt, Julien, Costa-Nunes, Carla-Marisa, Bordry, Natacha, Guillaume, Philippe, Luescher, Immanuel, Speiser, Daniel E., Rufer, Nathalie, Hebeisen, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399405/ https://www.ncbi.nlm.nih.gov/pubmed/36032094 http://dx.doi.org/10.3389/fimmu.2022.973986

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