Dynamic change of IDO1 activity predicts survival in patients with unresectable stage III NSCLC and chemoradiotherapy

OBJECTIVE: High activity of Indoleamine 2,3-dioxygenase1 (IDO1) in lung cancer patients converts tryptophan (Trp), which is the essential amino acid for T-cell metabolism, to kynurenine (Kyn) and consequently suppresses anti-tumor immune responses. We aimed to track the dynamics of IDO1 activity in...

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Detalles Bibliográficos
Autores principales: Wu, Linfang, Wang, Daquan, Chen, Yanhua, Qian, Mingmin, Xu, Xin, Zhang, Tao, Bi, Nan, Wang, Luhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399602/
https://www.ncbi.nlm.nih.gov/pubmed/36032151
http://dx.doi.org/10.3389/fimmu.2022.906815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399602/
https://www.ncbi.nlm.nih.gov/pubmed/36032151
http://dx.doi.org/10.3389/fimmu.2022.906815

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