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Dynamic change of IDO1 activity predicts survival in patients with unresectable stage III NSCLC and chemoradiotherapy
OBJECTIVE: High activity of Indoleamine 2,3-dioxygenase1 (IDO1) in lung cancer patients converts tryptophan (Trp), which is the essential amino acid for T-cell metabolism, to kynurenine (Kyn) and consequently suppresses anti-tumor immune responses. We aimed to track the dynamics of IDO1 activity in...
Autores principales: | Wu, Linfang, Wang, Daquan, Chen, Yanhua, Qian, Mingmin, Xu, Xin, Zhang, Tao, Bi, Nan, Wang, Luhua |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399602/ https://www.ncbi.nlm.nih.gov/pubmed/36032151 http://dx.doi.org/10.3389/fimmu.2022.906815 |
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