Inhibition mechanism of alpha-amylase, a diabetes target, by a steroidal pregnane and pregnane glycosides derived from Gongronema latifolium Benth

Alpha-amylase is widely exploited as a drug target for preventing postprandial hyperglycemia in diabetes and other metabolic diseases. Inhibition of this enzyme by plant-derived pregnanes is not fully understood. Herein, we used in vitro, in silico, and in vivo studies to provide further insights in...

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Detalles Bibliográficos
Autores principales: Ogunyemi, Oludare M., Gyebi, Gideon A., Saheed, Afolabi, Paul, Jesse, Nwaneri-Chidozie, Victoria, Olorundare, Olufunke, Adebayo, Joseph, Koketsu, Mamoru, Aljarba, Nada, Alkahtani, Saad, Batiha, Gaber El-Saber, Olaiya, Charles O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399641/
https://www.ncbi.nlm.nih.gov/pubmed/36032689
http://dx.doi.org/10.3389/fmolb.2022.866719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399641/
https://www.ncbi.nlm.nih.gov/pubmed/36032689
http://dx.doi.org/10.3389/fmolb.2022.866719

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