Structural insight into ASH1L PHD finger recognizing methylated histone H3K4 and promoting cell growth in prostate cancer

ASH1L is a member of the Trithorax-group protein and acts as a histone methyltransferase for gene transcription activation. It is known that ASH1L modulates H3K4me3 and H3K36me2/3 at its gene targets, but its specific mechanism of histone recognition is insufficiently understood. In this study, we f...

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Detalles Bibliográficos
Autores principales: Yu, Miaomiao, Jia, Yanjie, Ma, Zhanchuan, Ji, Donglei, Wang, Chunyu, Liang, Yingying, Zhang, Qiang, Yi, Huanfa, Zeng, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399681/
https://www.ncbi.nlm.nih.gov/pubmed/36033518
http://dx.doi.org/10.3389/fonc.2022.906807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399681/
https://www.ncbi.nlm.nih.gov/pubmed/36033518
http://dx.doi.org/10.3389/fonc.2022.906807

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