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Modelling predicts differences in chimeric antigen receptor T-cell signalling due to biological variability
In recent decades, chimeric antigen receptors (CARs) have been successfully used to generate engineered T cells capable of recognizing and eliminating cancer cells. The structure of CARs typically includes costimulatory domains, which enhance the T-cell response upon antigen encounter. However, it i...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399690/ https://www.ncbi.nlm.nih.gov/pubmed/36039281 http://dx.doi.org/10.1098/rsos.220137 |