Elevated levels of the methyltransferase SETD2 causes transcription and alternative splicing changes resulting in oncogenic phenotypes

The methyltransferase SETD2 regulates cryptic transcription, alternative splicing, and the DNA damage response. It is mutated in a variety of cancers and is believed to be a tumor suppressor. Counterintuitively, despite its important role, SETD2 is robustly degraded by the proteasome keeping its lev...

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Detalles Bibliográficos
Autores principales: Bhattacharya, Saikat, Reddy, Divya, Zhang, Ning, Li, Hua, Workman, Jerry L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399737/
https://www.ncbi.nlm.nih.gov/pubmed/36035998
http://dx.doi.org/10.3389/fcell.2022.945668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399737/
https://www.ncbi.nlm.nih.gov/pubmed/36035998
http://dx.doi.org/10.3389/fcell.2022.945668

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