Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons

Hippocampal neurogenesis is impaired in Alzheimer’s disease (AD) patients and familial Alzheimer’s disease (FAD) mouse models. However, it is unknown whether new neurons play a causative role in memory deficits. Here, we show that immature neurons were actively recruited into the engram following a...

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Detalles Bibliográficos
Autores principales: Mishra, Rachana, Phan, Trongha, Kumar, Pavan, Morrissey, Zachery, Gupta, Muskan, Hollands, Carolyn, Shetti, Aashutosh, Lopez, Kyra Lauren, Maienschein-Cline, Mark, Suh, Hoonkyo, Hen, Rene, Lazarov, Orly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399756/
https://www.ncbi.nlm.nih.gov/pubmed/35984475
http://dx.doi.org/10.1084/jem.20220391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399756/
https://www.ncbi.nlm.nih.gov/pubmed/35984475
http://dx.doi.org/10.1084/jem.20220391

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