Allosteric regulation of autoinhibition and activation of c-Abl

c-Abl, a non-receptor tyrosine kinase, regulates cell growth and survival in healthy cells and causes chronic myeloid leukemia (CML) when fused by Bcr. Its activity is blocked in the assembled inactive state, where the SH3 and SH2 domains dock into the kinase domain, reducing its conformational flex...

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Detalles Bibliográficos
Autores principales: Liu, Yonglan, Zhang, Mingzhen, Tsai, Chung-Jung, Jang, Hyunbum, Nussinov, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399898/
https://www.ncbi.nlm.nih.gov/pubmed/36051879
http://dx.doi.org/10.1016/j.csbj.2022.08.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399898/
https://www.ncbi.nlm.nih.gov/pubmed/36051879
http://dx.doi.org/10.1016/j.csbj.2022.08.014

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